Supplemento 5HTP ha guadagnato crescente popolarità per una serie di motivi ampiamente diverse. Si tratta di un controllo dell’appetito legale integratore? Funziona per il corpo?
Qual è 5HTP
5HTP (5Hydroxytryptophan) è una sostanza naturale derivata dai baccelli del seme di Griffonia simplicifolia, una pianta medicinale dell’Africa occidentale. Negli esseri umani, 5HTP è il nutrimento immediato precursore del neurotrasmettitore serotonina.
Ciò significa che 5HTP converte direttamente in serotonina nel cervello. La serotonina ha molte funzioni profondamente importanti, tra cui un ruolo nel sonno, l’appetito, la memoria, l’apprendimento, la regolazione della temperatura, l’umore, il comportamento sessuale, la funzione cardiovascolare, la contrazione muscolare e regolazione endocrina.
5HTP è pillola migliore controllo dell’appetito
Serotonin levels seem to play an important role in appetite and, thus, weight control. A diet low in tryptophan seems to lead to low brain serotonin levels, which in turn results in the brain sensing starvation and stimulating the appetite. The role of 5HTP in increasing serotonin levels creates a feeling of satiety, which may lead to curbed appetite and, consequently, weight loss.
Some studies indicate that when taken before meals, 5HTP may lead to a more rapid feeling of satiety. In a 1989 Italian study of 19 overweight females with a body mass index (BMI) between 30 and 40, the women received either 8 mg of 5HTP per kg of body weight or placebo before meals for five weeks. No dietary restrictions were prescribed so that researchers could evaluate the effect of 5HTP in reducing appetite and promoting weight loss without any conscious effort to prohibit certain foods.
The average amount of weight loss during the 5-week period of 5HTP supplementation was a little more than 3 pounds, compared with less than 1 pound of total weight loss during the placebo period. The women taking 5HTP felt full faster than those taking placebo and, as a result, dramatically reduced caloric intake. Subsequent studies restricted the subjects to specific dietary recommendations.
In a double-blind study in 1991 also in Italy, 14 overweight females with a body mass index between 30 and 40 and a tendency to overeat, received either 300 mg of 5HTP or placebo 30 minutes before meals for a 12-week study. During the firsts six weeks there were no dietary recommendations, but during the second six-weeks the women were placed on a 1,200-Calorie diet.
Women receiving 5HTP treatment collectively lost more than 10 pounds, while the women taking placebo lost slightly more than two pounds, and all women taking 5HTP reported feeling satiated faster than those taking placebo. However, some women receiving treatment reported some aversion to meat or altered taste and smell, and most experienced mild nausea during the first six weeks of the trial which abated in the last six weeks.
In a 1992 trial similarly designed by the same lead author and evaluating 28 overweight subjects with dietary restrictions during the second six-week period, those receiving 300 mg of 5HTP before each meal lost significantly more weight than those taking placebo.
Those taking placebo had trouble adhering to the restricted diet. By contrast, 100 percent of subjects in the treatment group reported early satiety during the first six-week period and 90 percent reported the same during the second six-week period, thereby adhering to the restricted diet and reducing caloric intake.
In addition, because 5HTP reportedly reduces cravings for sweets and starches, it may also be of use in helping diabetics adhere to a healthy diet. In a 1998 double-blind, placebo-controlled, randomized Italian study by the same lead author as the above studies, 25 overweight non-insulin dependent diabetic outpatients received either 750 mg of 5HTP daily or placebo for two consecutive weeks with no dietary restrictions.
Results here also indicated that patients receiving 5HTP significantly decreased their daily energy intake, by reducing carbohydrate and Fat intake, and reduced their body weight.
Conclusion about 5HTP
Some studies have shown the supplement is an effective anti-depressant and can help people similarly to prescription medications. Other studies have proven it works to help people with overeating. They have also seen positive results on people with fibromyalgia, migraines, and sleeplessness. Although serotonin toxicity has not been observed in humans with coingestion of 5HTP and anti-depressants, it is advised to consult your doctor if deciding to pair the two.
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